Academic Output
Publications
Peer-reviewed articles and research contributions from our laboratory.
2025
3 papersErbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer
Jaekwang Jeong, Kwangmin Yoo, Jongwon Lee, Jae Hun Shin, Jungmin Choi, John Wysolmerski
Breast Cancer ResearchDOIFully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency
Jinkyu Park, Muhammad Riaz, Lingfeng Qin, Wei Zhang, Luke Batty, Saba Fooladi, Mehmet H Kural, Xin Li, Hangqi Luo, Zhen Xu, Juan Wang, Kimihiko Banno, Sean X Gu, Yifan Yuan, Christopher W Anderson, Matthew W Ellis, Jiahui Zhou, Jiesi Luo, Xiangyu Shi, Jae Hun Shin, Yufeng Liu, Seoyeon Lee, Mervin C Yoder, Robert W Elder, Michael Mak, Stephanie Thorn, Albert Sinusas, Peter J Gruber, John Hwa, George Tellides, Laura E Niklason, Yibing Qyang
Cell Stem CellDOITrogocytosis-mediated immune evasion in the tumor microenvironment
Jeonghyun Kim, Soyeon Park, Jungseo Kim, Yewon Kim, Hong Min Yoon, Bima Rexa Rayhan, Jaekwang Jeong, Alfred LM Bothwell, Jae Hun Shin
Experimental & Molecular MedicineDOI
2024
3 papersIntracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution
Jaekwang Jeong, Jongwon Lee, Gabriel Talaia, Wonnam Kim, Junho Song, Juhyeon Hong, Kwangmin Yoo, David G Gonzalez, Diana Athonvarangkul, Jaehun Shin, Pamela Dann, Ann M Haberman, Lark Kyun Kim, Shawn M Ferguson, Jungmin Choi, John Wysolmerski
Cellular and Molecular Life SciencesDOIMetastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties
Jae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K Dinesh, Stephen E Maher, Jeonghyun Kim, Soyeon Park, Jun Young Hong, John Wysolmerski, Jungmin Choi, Alfred LM Bothwell
eLifeDOIIntercellular transfer of immune regulatory molecules via trogocytosis
Soyeon Park, Jeonghyun Kim, Jae Hun Shin
Intercellular and Interorganellar Transfer and Communication in Biology and MedicineDOI
2022
2 papers2021
3 papersMAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells
Jaekwang Jeong, Jae Hun Shin, Wenxue Li, Jun Young Hong, Jaechul Lim, Jae Yeon Hwang, Jean-Ju Chung, Qin Yan, Yansheng Liu, Jungmin Choi, John Wysolmerski
Cell ReportsDOIColon cancer cells acquire immune regulatory molecules from tumor-infiltrating lymphocytes by trogocytosis
Jae Hun Shin, Jaekwang Jeong, Stephen E Maher, Heon-Woo Lee, Jaechul Lim, Alfred LM Bothwell
Proceedings of the National Academy of SciencesDOIDickkopf-2 regulates the stem cell marker LGR5 in colorectal cancer via HNF4α1
Jae Hun Shin, Jaekwang Jeong, Jungmin Choi, Jaechul Lim, Ravi K Dinesh, Jonathan Braverman, Jun Young Hong, Stephen E Maher, Maria C Amezcua Vesely, WonJu Kim, Ja-Hyun Koo, Wenwen Tang, Dianqing Wu, Holly N Blackburn, Rosa M Xicola, Xavier Llor, Omer Yilmaz, Je-Min Choi, Alfred LM Bothwell
IscienceDOI
2017
1 paperMutant CTLA4 gene transfected T cell and composition including same for anticancer immunotherapy
Kyungho Choi, Jaehun Shin, Sang-jin Lee
2016
3 papersBBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis
Sangho Lim, Won-Ju Kim, Yeon-Ho Kim, Sohee Lee, Ja-Hyun Koo, Jung-Ah Lee, Hye-Mi Kim, Hong-Jai Park, Do-Hyun Kim, Hong-Gyun Lee, Heeseok Yoon, Ji Yun Kim, Jae Hun Shin, Lark Kyun Kim, Junsang Doh, Hongtae Kim, Alfred L Bothwell, Sang-Kyou Lee, Minah Suh, Je-Min Choi
The Journal of ImmunologyDOIEnhanced Anti-tumor Reactivity of Cytotoxic T Lymphocytes Expressing PD-1 Decoy
Jae Hun Shin, Hyung Bae Park, Kyungho Choi
Immune NetworkDOIThe Wnt antagonist Dickkopf-1 promotes pathological type 2 cell-mediated inflammation
Wook-Jin Chae, Allison K Ehrlich, Pamela Y Chan, Alexandra M Teixeira, Octavian Henegariu, Liming Hao, Jae Hun Shin, Jong-Hyun Park, Wai Ho Tang, Sang-Taek Kim, Stephen E Maher, Karen Goldsmith-Pestana, Peiying Shan, John Hwa, Patty J Lee, Diane S Krause, Carla V Rothlin, Diane McMahon-Pratt, Alfred LM Bothwell
ImmunityDOI
2015
2 papersNdrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2
Yu Mi Oh, Hyung Bae Park, Jae Hun Shin, Ji Eun Lee, Ha Young Park, Dhong Hyo Kho, Jun Sung Lee, Heonsik Choi, Tomohiko Okuda, Koichi Kokame, Toshiyuki Miyata, In-Hoo Kim, Seung Hoon Lee, Ronald H Schwartz, Kyungho Choi
Nature communicationsDOIdNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis
Sangho Lim, Won-Ju Kim, Yeon-Ho Kim, Sohee Lee, Ja-Hyun Koo, Jung-Ah Lee, Heeseok Yoon, Do-Hyun Kim, Hong-Jai Park, Hye-Mi Kim, Hong-Gyun Lee, Ji Yun Kim, Jae-Ung Lee, Jae Hun Shin, Lark Kyun Kim, Junsang Doh, Hongtae Kim, Sang-Kyou Lee, Alfred LM Bothwell, Minah Suh, Je-Min Choi
Nature communicationsDOI
2013
1 paperAdenovirus expressing both thymidine kinase and soluble PD1 enhances antitumor immunity by strengthening CD8 T-cell response
Seung-Pil Shin, Hye-Hyun Seo, Jae-Hun Shin, Hyung-Bae Park, Dong-Pyo Lim, Hyeon-Seok Eom, Yong-Soo Bae, In-Hoo Kim, Kyungho Choi, Sang-Jin Lee
Molecular TherapyDOI
2012
1 paperPositive conversion of negative signaling of CTLA4 potentiates antitumor efficacy of adoptive T-cell therapy in murine tumor models
Jae Hun Shin, Hyung Bae Park, Yu Mi Oh, Dong Pyo Lim, Ji Eun Lee, Hae Hyun Seo, Sang Jin Lee, Hyeon Seok Eom, In-Hoo Kim, Seung Hoon Lee, Kyungho Choi
BloodDOI
2010
1 paperCell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation
Je-Min Choi, Jae-Hun Shin, Myung-Hyun Sohn, Martha J Harding, Jong-Hyun Park, Zuzana Tobiasova, Da-Young Kim, Stephen E Maher, Wook-Jin Chae, Sung-Ho Park, Chun-Geun Lee, Sang-Kyou Lee, Alfred LM Bothwell
Proceedings of the National Academy of SciencesDOI
2008
1 paperTransduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis
Je-Min Choi, Seung-Hyung Kim, Jae-Hoon Shin, Thomas Gibson, Byoung-Seok Yoon, Dong-Ho Lee, Seung-Kyou Lee, Alfred LM Bothwell, Jong-Soon Lim, Sang-Kyou Lee
Proceedings of the National Academy of SciencesDOI
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